Octocog alfa

Adult: Treatment: Dosage is individualised based on the severity of deficiency, location and extent of bleeding, and patient's clinical condition. Generally, admin of factor VIII 1 IU/kg will increase circulating factor VIII levels by approx 2 IU/dL. Recommendation: Minor bleeding: 10-20 IU/kg 12-24 hrly for approx 1-3 days. Moderate bleeding: 15-30 IU/kg 12-24 hrly for approx ≥3 days. Major bleeding: 30-50 IU/kg 8-24 hrly until bleeding resolves. Minor surgery: 30-50 IU/kg as a single dose w/in 1 hr of the procedure; repeat after 12-24 hr as needed. Major surgery: 40-60 IU/kg pre-op, repeated 8-24 hrly depending on state of wound healing. Prophylaxis: 20-40 IU/kg 3-4 times wkly. Doses are given via infusion over ≤5 min at max rate of 10 mL/min.
Child: Treatment: Same as adult dose. Patients <6 yr may require more frequent admin: 8-24 hrly (minor/moderate bleeding); 6-12 hrly (major bleeding); 6-24 hrly (major surgery). Prophylaxis: <6 yr 20-50 IU/kg 3-4 times wkly; ≥6 yr Same as adult dose.